Open Access Open Badges Case report

Early bioprosthetic valve calcification with alfacalcidol supplementation

Tamaki Takano*, Takamitsu Terasaki, Yuko Wada, Noburou Ohashi, Kazunori Komatsu, Daisuke Fukui and Jun Amano

Author Affiliations

Department of Cardiovascular Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Japan

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Journal of Cardiothoracic Surgery 2013, 8:11  doi:10.1186/1749-8090-8-11

Published: 16 January 2013


We report a case of early bioprosthetic valve calcification in a 76 year-old woman who had received supplementation with alfacalcidol, an analogue of vitamin D, for 3 years after her initial valve replacement. She underwent aortic valve replacement at the age of 71 and subsequently complained of shortness of breath. Ultrasonic cardiography revealed severe aortic stenosis and we performed a second aortic valve replacement with a bioprosthesis. Histopathologic and x-ray examination showed calcification on the explanted valve. She had not presented with any known risk for early bioprosthetic calcification, suggesting that vitamin D supplementation may accelerate calcification of bioprosthetic valves.

Prosthesis; Biomaterials; Aortic valve; Replacement; Calcification; Heart valve; Bioprosthesis