Email updates

Keep up to date with the latest news and content from Journal of Cardiothoracic Surgery and BioMed Central.

Open Access Case report

An unusual case of giant cell myocarditis missed in a Heartmate-2 left ventricle apical-wedge section: a case report and review of the literature

Kim Anderson1, Michel Carrier2, Philippe Romeo3, Guy B Pelletier1, Mark Liszkowski1, Normand Racine1, Michel White1 and Anique Ducharme1*

Author Affiliations

1 Department of Medicine, Montreal Heart Institute, University of Montreal, 5000, Belanger East, Montreal, QC, H1T 1C8, Canada

2 Department of Cardiac Surgery, Montreal Heart Institute, University of Montreal, 5000, Belanger East, Montreal, QC, H1T 1C8, Canada

3 Department of Pathology, Montreal Heart Institute, University of Montreal, 5000, Belanger East, Montreal, QC, H1T 1C8, Canada

For all author emails, please log on.

Journal of Cardiothoracic Surgery 2013, 8:12  doi:10.1186/1749-8090-8-12

Published: 17 January 2013

Abstract

Herein we present a case of fulminant myocarditis in a woman previously treated for B-cell lymphoma. While the clinical context was suggestive of adriamycin-induced cardiomyopathy, the initial pathology of the Heartmate-2 apical core showed lymphocytic myocarditis. After 8 months of stability, the patient presented with progressive heart failure and recurrent ventricular arrhythmias. An endomyocardial biopsy revealed findings typical of giant cell myocarditis (GCM); poor response to immunosuppressive therapy and marked hemodynamic instability led to urgent transplantation. To our knowledge, this is the first reported case of GCM following an acute lymphocytic myocarditis and the second GCM case associated with B-cell lymphoma.

Keywords:
Giant cell myocarditis; Lymphocytic myocarditis; Lymphoma; Immunosuppression; Heart transplant; Endomyocardial biopsy; Left ventricular assist device